![]() In addition, many sample preparation techniques have the potential to impact the structure and properties of virus particles and VLPs.Īs a non-invasive method, dynamic light scattering (DLS) offers many advantages over more traditional approaches such as microscopy, which often require manipulations that can alter the particles, according to Sophia Kenrick, an application scientist with Wyatt Technology. Detection of VLPs can be a challenging task, and any detection method must be able to differentiate virus and VLP particles-which range from tens to hundreds of nm-from proteins. VLPs are designed to mimic the activity of viruses via viral surface proteins, but they lack the infectious genetic material of viruses. This book should be of interest to researchers in physics, physical chemistry, biophysics and medical biophysics.Effective analysis of viruses and virus-like particles (VLPs) is crucial for the development of vaccines and drugs. Chapters are to be found on multicomponent mixtures, polyelectrolytes, dense polymer systems, gels, rigid rods, micellar systems and the application of dynamic light scattering to biological systems. The second aim is to illustrate the widely varying fields in which the technique finds application. Theoretical developments relating dynamic light scattering to the viscoelasticity of polymers in solution and in the bulk are described. This volume is directed in part to the philosophy and current practice in dynamic light scattering: single photon correlation techniques are introduced, a discussion of noise on photon correlation functions is given and data analysis in dynamic light scattering to polymer structure analysis is presented and a comprehensive introduction to diffusing wave spectroscopy is given. ![]() It can be employed on extremely small fluid volumes, the instrumentation is relatively inexpensive and allows the rapid determination of diffusion coefficients as well as providing information on relaxation time distributions for the macromolecular components of complex systems. The importance of the technique lies in its non-invasive character. application of dynamic light scattering to biological systemsĭynamic light scattering is a new method for investigating macromolecular systems. ![]()
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